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Drugs in the antihypertensives class are used to treat hypertension (high blood pressure). Stroke and myocardial infarction are two consequences of high blood pressure that are targeted by antihypertensive medication. According to the evidence, lowering blood pressure by 5 mmHg can lower the risk of stroke by 34%, ischemic heart disease by 21%, dementia, heart failure, and cardiovascular disease-related mortality. Antihypertensives come in a variety of classes and work to reduce blood pressure in various ways. Thiazide diuretics, calcium channel blockers, ACE inhibitors, angiotensin II receptor antagonists (ARBs), and beta blockers are some of the most significant and frequently used medications.
National guidelines have been produced as a result of numerous sizable investigations on the best type of drug to start with for treating hypertension. Preventing major endpoints of hypertension, like heart attack, stroke, and heart failure should be the main focus of treatment. age of the patient,
. The best available research, as of 2009, suggests thiazide diuretics as the first-line treatment of choice for high blood pressure when medication is required. Although clinical data indicate that calcium channel blockers and thiazide-type diuretics are the majority of patients' preferred first-line therapies (from the perspectives of efficacy and cost), an ACE inhibitor is advised by NICE in the UK for those under the age of 55
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11.2. Central action adrenomimetics
Clonidine and Methyldopa
11.3. Peripheral action drug
Adrenoblockers: beta- 1, beta- 2 adrenoblockers & beta –1 cardioselective
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