DRUGS FOR ANGIOTENSIN

 1.4. Medicines that inhibit angiotensin II

A class of medications that affect the renin-angiotensin system is referred to as angiotensin II receptor antagonists, commonly known as angiotensin receptor blockers (ARBs), AT1-receptor antagonists, or satans. Their primary applications are in the management of congestive heart failure, diabetic nephropathy, and hypertension (high blood pressure).

When a patient cannot tolerate ACE inhibitor therapy for their hypertension, angiotensin II receptor blockers are generally employed. They rarely result in persistent dry cough and/or angioedema that restrict the use of ACE inhibitor therapy because they do not affect the breakdown of Bradykinin or other kinins. [Reference needed] They have more recently been utilized, particularly candesartan, to treat heart failure in patients who are intolerant of ACE inhibitor medication. According to trial results, losartan and irbesartan are beneficial for hypertensive type II diabetic patients and may halt the progression of diabetic nephropathy. [Reference needed] A 1998In contrast to losartan, lisinopril improved insulin sensitivity, according to a 1998 double-blind research. [1]Candesartan is an investigational therapy for migraine prevention. [2] [3]Candesartan has been reported to be more frequently beneficial at preventing migraines than lisinopril. [4]

Different angiotensin II receptor blockers have different blood pressure-lowering effects, and even at the highest doses, these effects are statistically different.

The specific agent employed in clinical practice may change depending on the needed level of response.