DRUGS ACTING ON GIT TRACKS

7.2. Antihistamines that reduce gastric acid secretion

 (a) H2 antihistamines: Cimetidine, Ranitidine,

Roxatidine and famotidine

Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, S (-) Pantoprazole, and Rabeprazole are proton pump inhibitors.

Pirenzepine and propantheline are anticholinergics.

[c] Misoprostol is a prostaglandin analogue.

neutralizers for stomach acid (Antacids)

(a) Systemic: Sod. citrate and sodium bicarbonate

(b) Nonsystemic: Calcium carbonate, magnesium hydroxide, magnesium trisilicate, aluminium hydroxide gel, and magaldrate

7.4. Ulcer protectives

Sucralfate and Colloidal bismuth subcitrate (CBS)

 7..5. Anti-Helicobacter pylori drugs

An Amoxicillin, Clarithromycin, Metronidazole, Tinidazole, Tetracycline

7.6.antiemetics(anti-vomiting drug}

 An Amoxicillin, Clarithromycin, Metronidazole, Tinidazole, Tetracycline

1. Anticholinergics: Hyoscine, Dicyclomine

7.8. Laxatives(Purgatives, Cathartics)

Bulk forming agents: dietary fibre - Bran, Psyllium (Plantago), Ispaghula, Methylcellulose

Stool softener:  Docusates (DOSS), Liquid paraffin

Stimulant purgatives: Phenolphthalein, Bisacodyl, Sodium picosulfate, Anthraquinones (Emodins), Senna, Cascara sagrada

Fixed oil: Castor oil

Osmotic purgatives: Magnesium sulfate, hydroxide, Sodium sulfate, Lactulose

7.9. Drug to treat acute  and chronic pancreatitis

Aprotinin                          pancreatin

 Octreotid                               

2. H1 antihistaminics: Promethazine, Diphenhydramine,Dimenhydrinate, Doxylamine

3. Neuroleptics: Chlorpromazine, Prochlorperazineand Haloperidol, etc.

4. Prokinetic drugs: Metoclopramide, Domperidone and Cisapride

5. 5-HT3 antagonists: Ondansetron, Granisetron

7.7. Drugs for Gastroesophageal Reflux Disease (GERD)

Inhibitors/neutralizers of gastric acid secretion

1. Proton pump inhibitors (PPIs): Omeprazole,

Pantoprazole and others.

2. H2 blockers: Ranitidine, Famotidine

3. Antacids: Magnesium hydroxide, Aluminium hydroxide

4. Barrier agent - Sodium alginate

5. Prokinetic drugs: (Enhance LES tone and promote gastric emptying)

Cisapride, Mosapride, Metoclopramide

7.8. Laxatives(Purgatives, Cathartics)

Bulk forming agents: dietary fibre - Bran, Psyllium (Plantago), Ispaghula, Methylcellulose

Stool softener:  Docusates (DOSS), Liquid paraffin

Stimulant purgatives: Phenolphthalein, Bisacodyl, Sodium picosulfate, Anthraquinones (Emodins), Senna, Cascara sagrada

Fixed oil: Castor oilrgatives: Magnesium sulfate, hydroxide, Sodium sulfate, Lactulose

7.9. Drug to treat acute  and chronic pancreatitis

Osmotic pu

Aprotinin                                 pancreatin

 Octreotid